Enhancement by retinoid of hemin-induced differentiation of human leukemia K562 cell line
نویسندگان
چکیده
منابع مشابه
Human Leukemia Cell Line K562 Responds
We report that erythroid-potentiating activity (EPA). known to stimulate the proliferation of normal human erythroid precursors in vitro. has a growth-promoting effect on human K562 erythroleukemia cells and Friend mouse erythroleukemia cells. Detailed studies were carried out using an EPA produced by a human T-lymphoblast line (Mo). Although EPA has not been purified to homogeneity. several ob...
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متن کاملGanglioside GM3 can induce megakaryocytoid differentiation of human leukemia cell line K562 cells.
The role of acidic glycosphingolipids in cell growth and differentiation was investigated using the multipotent leukemia cell line K562. When GM3 was added to cell culture media, the growth of K562 cells was remarkably inhibited and the cells were shown to have megakaryocytoid morphology. Ultrastructural study demonstrated that K562 cells treated with GM3 had platelet peroxidase-positive struct...
متن کاملDiffering responses of globin and glycophorin gene expression to hemin in the human leukemia cell line K562.
The human leukemia cell line, K562, produces embryonic and fetal hemoglobins and glycophorin A, proteins normally associated only with erythroid cells. Hemoglobin accumulation is enhanced by exposure of the cells to 0.05 mM hemin. We have examined K562 cells before and after exposure to hemin to determine whether expression of these erythroid proteins was shared by all cells or confined to spec...
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ABSTRACT Background and objective: Considering the toxic side effects of chemotherapy in treatment of cancer, anticancer drugs of natural origin including probiotic Lactobacillus strains have recently attracted a lot of attention. Methods: After culturing chronic myeloid leukemia cell line K562 in 96-well plates, effects of different concentrations of ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1993
ISSN: 0014-5793
DOI: 10.1016/0014-5793(93)80924-j